|www.petdiabetes.com & www.caninediabetes.org
recommends that you buy the following blood meter
that has just been released to test your pet's glucose.
Margo has kindly provided the following information
Who is Kristine Dahl??
The following information is from an email sent to Margo from Dr. Dahl.
For a quick background on me. I think it is important for you to know
my background given
the type of problem we are tackling with whole blood measurements in
animals. I have a Ph.D.
in Biochemistry and was trained as an endocrinologist. I was an Assoc.
Prof. of Medicine at the
Univ of Wash, Seattle before I left to start a series of companies
which primary focused on
validating equipment and tests for animal use. I have been developing
animal tests for 25 years.
The reasons for the inherent problems with the glucometers that are
sold for human use
is the red blood cell size differences between humans and most other
Glucose strips come in 2 basic formats: colorimetric
Colorimetric strips are where a drop of blood on top of the strip causes
a color change
in the reagents on the bottom of the strip. Therefore you can visually
see the color change.
Amphoteric strips are where addition of blood to the strip causes a
change in current that is
read by the meter. Irrespective of the type of strips you use the meter
can be off
by 10% to 70% depending on whether the value is high or low.
Even when you get it right for a particular lot of strips the next
lot can be totally different.
Why is this so???? The reason is that the strip has a series
of membranes which have different
purposes. The top membrane is responsible for excluding the red blood
cells and the bottom
membrane is where the glucose in the sample causes a reaction to produce
either a color change
or current. The top membrane is designed specifically for the human
red blood cell which is
approximately 7 um in size. So all the validation tests are performed
on that red blood cell size.
A dog or cat has a red blood cell size of 4-5 um, i.e. smaller.
Smaller red blood cell sizes blocks the membrane pores.
Now you have changed the ability of the glucose to flow through to
the bottom pad.
It's sort of like a sponge where if you pore water through a nice clean
sponge it comes our
the bottom pretty quickly versus if you pore flour on the sponge and
then try to pore water
through you will get the water eventually but at a much slower pace.
Since glucose measurements
are timed you are only going to measure the amount of glucose that
gets to the bottom membrane in the allotted time.
In dog's and cat's case you will only measure a fraction
of the glucose in the sample. Adding to the above problem is when the
manufacturers get new
materials for their top membrane they only test it on human blood cells.
I'm sure you're asking how do we get around this? The only way
is to forget all about how
the membranes react to human blood and concentrate on developing reaction
curves to animal
blood. Luckily cats, dogs and horses have similar red blood cell sizes.
The other hurdle was
convincing a manufacturer that it was worth while to develop one of
their meters for animal use.
I have already conquered the former and I have finally accomplished
the later. There is hope
on the horizon if I can get 20 home user beta sites that are dedicated
to this end. We are planning
on having 20 vet clinic sites (picked by the manufacturer) and 20 home
user beta sites.
The project is tentatively scheduled to begin the end of this month
and the product released in early Jan.
I will be running the project and will continue to validate the lots
of strips in the future.
Margo's canine Alex was one of the home users that tested this
new meter and Margo herself is also a diabetic making her
knowledge of this disease outstanding.
Click here to find out
more about this meter and how to purchase it today!!
Testing your pet's glucose at home will help you to save costs at your
make it easier to gain control of your pet's diabetes.
Picture tutorials on how to do hometesting
Blood Testing Picture Tutorials
This page was updated on April 16, 2008